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Diane Brzezinski, D.O. FACOI

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Dr. B's Blog

weight loss peptide program with Dr. B


If you follow celebrity news, you’ve undoubtedly heard the buzz about Ozempic, a Type 2 Diabetes drug that stars and influencers have been using off-label to lose weight rapidly. If you keep abreast of weight-loss drug development, you’ve probably heard about FDA-approved Wegovy, which experienced soaring patient demand and shortages in 2023.

You might not know that the active ingredient in both products is Semaglutide, a peptide that internal medicine specialist Dr. Diane Brzezinski, D.O., has used for years in one of her medical weight-loss programs.

In fact, Semaglutide is just one of several peptides Dr. B uses to help her Naples, Florida-area patients lose weight. Let’s look closer at how Dr. B’s weight loss peptide therapy can help you lose weight and improve overall health.


Peptides are chemical compounds composed of amino acid chains that living organisms use for numerous physiological functions. Our bodies can absorb and utilize peptides made by meat, fish, and plants and produce their own peptides by joining amino acids. Researchers have identified at least a thousand distinct peptides and continually discover new ones.

The physiological purpose and potential health benefits of peptides depend on the sequence of their amino acids. Researchers refer to those with known health benefits as bioactive peptides. These are increasingly used in weight loss and other health-related supplements. Physiological functions identified in weight-loss peptides include:

  • Signal the body to burn fatty acids in fat cells before using carbohydrates or glucose.
  • Moderate blood sugar levels to slow digestion and decrease appetite.
  • boost the production of human growth hormone (HGH) to stimulate lean muscle growth.
  • Enhance calorie-burning metabolism levels.

Because our natural peptide production declines as we age, bioactive peptides can help restore the natural cell functioning of our youth and enhance the body’s ability to control weight gain. Weight-loss peptides are most effective when combined with diet and exercise. For example, HGH-enhancing peptides stimulate lean muscle growth, which increases the caloric burn rate of exercise.


Dr. B’s Weight Loss Peptide program in Naples is customized for each patient to address specific peptide deficiencies, optimize weight loss, and provide other health benefits as warranted. Dr. B administers peptides orally, topically, or via injection, depending on the peptide used and the health condition(s) she’s treating. Her primary peptide options include:


This peptide—and derived Ozempic and Wegovy prescription medications—lowers blood sugar levels to help increase insulin production, which in turn helps reduce body fat by slowing digestion and suppressing appetite. With over four years of developing her comprehensive Semaglutide weight-loss program, Dr. B sources her Semaglutide from a Peptide Creating Pharmacy that is highly regulated by the FDA. The formulation is combined with Vitamin B6 or B12, which enhances weight reduction helps negate potential gastrointestinal side effects. It has also undergone clinical studies that demonstrate its cardiac benefits and renal protection.

Dr. B cautions patients that numerous foreign compounding pharmacies are producing Semaglutide formulations that have not been reviewed or approved by the FDA. While these formulations are not supposed to be marketed in the U.S., some companies are marketing these Semaglutide preparations on social media and offering injections at their clinics. In many cases, these Semaglutide injections are delivered without medical supervision and follow-up monitoring of the patient’s health. While the FDA is cracking down on Semaglutide marketing by such compounding pharmacies, the surge in Semaglutide popularity has made this challenging. Dr. B recommends that anyone seeking Semaglutide should consult directly with a medical professional. This ensures that they will receive an FDA-approved formulation.


The potent anti-inflammatory properties in this peptide help reduce chronic inflammation that causes hormonal and metabolic responses that encourage weight gain. This peptide also boosts metabolism and improves energy levels to further promote weight loss, especially when combined with diet and exercise. Researchers also believe it helps reduce fat gene expression, giving it additional power as a weight loss peptide.


This HGH-stimulating peptide helps increase lean muscle mass, boosts energy, improves hormonal balance, and shreds fat. Dr. B typically combines this weight loss peptide in Naples with a customized diet and exercise program to produce dramatic weight reductions.


This supplement promotes the body’s natural fat-burning abilities with clinically studied compounds and natural peptide-containing ingredients that are deemed “generally recognized as safe” by the FDA.


Dr. B tends to see variable results from her Naples-area Weight Loss Peptide program patients. This is due to starting weights, differences in health profiles, metabolism, diet, exercise habits, and approved peptide therapy. Many of her patients can lose up to 10% of their body weight within four months. Some experience a 20% loss in just over a year. While some patients experience more moderate losses, others see dramatic results, especially when they are diligent about following any of her prescribed diet and exercise regimens.


The medical field uses peptides to address numerous health issues, and researchers frequently uncover new bioactive uses. Many health and cosmetic products now contain peptide adjuncts to provide distinct health benefits. This includes anti-inflammation, anti-aging, skin conditioning, and muscle building. Bioactive peptides are also used for:

  • Immune system response enhancement
  • Autoimmune disease control
  • Gastrointestinal issues
  • Collagen formation
  • Neurological issues
  • Wound healing and post-operative care
  • Age-related bone loss
  • Enhanced libido and sexual performance
  • Blood clot prevention
  • Blood pressure control
  • Joint pain
  • Soft-tissue injuries
  • Hair restoration


To learn how weight loss peptide therapy in Naples can help you shred pounds and improve overall health, schedule an appointment at Dr. B’s internal medicine practice at (239) 261-9990.