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Diane Brzezinski, D.O. FACOI

Call for an appointment | 239.261.9990

Medical Weight Loss

Medical weight loss naples fl

Dr. B – Trusted Weight Loss Doctors in Naples

Dr. Brzezinski, is one of the most highly experienced and trusted medical weight loss doctors in Naples, FL. Her internal medicine practice offers several effective weight loss programs including weight loss medication.

“Today, with obesity at epidemic proportions, everyone is thinking about weight loss and nutrition. As a board certified physician with a large internal medicine practice as well as a weight loss program, I have this conversation many times a day.”

Let’s face it, we all know how to eat. It just seems as if we need a push in the right direction. Our physician-supervised program is designed to do just that, and it can help you lose significant weight every month.

Using this multi-faceted approach including accountability, meal replacement, and in some cases weight loss medication, Dr. B can get you on the path to your ideal weight quickly and effectively.

Weight Loss Peptides

In recent years medical researchers have uncovered the significant role peptides serve in maintaining cellular function and regulating autoimmune responses. Similar to proteins but with smaller amino acid chains, our body naturally produces thousands of different peptides, many of which play critical roles in maintaining good health. As we age, though, our natural peptide production declines, which can diminish proper bodily functioning. Peptide supplements and therapies can help restore youthful peptide levels, which can help improve metabolism, promote faster cellular healing, and offer other health benefits, including enhanced weight management.

In unlocking the secrets of peptides, researchers have discovered that some play a significant role in metabolism, fat storage, insulin production, inflammation, and other factors that affect weight gains and losses. Dr. B closely follows peptide research developments and is pleased to offer her Naples, Florida-area patients peptide therapies that have shown clinical promise in helping patients lose and manage weight.


Type 2 Diabetes Treatment and Long-Term Weight Management

Semaglutide is a glucagon-like peptide 1 receptor agonist that helps lower blood sugar levels by increasing insulin production. Semaglutide works by stimulating the growth of pancreatic beta cells, which help synthesize and secrete insulin and inhibit the production of glucagon, a hormone that increases blood sugar. The peptide also helps reduce body fat by slowing digestion and suppressing one’s appetite. Initially approved by the FDA for type 2 diabetes in injectable form in 2017 and as an oral medication in 2019, the FDA expanded its approval as an adjunct to diet and exercise for long-term weight management in 2021.

Semaglutide is prescribed for chronic weight loss to patients with a body mass index of 30 or greater (clinically obese) and to anyone considered overweight who has a weight-related condition, such as type 2 diabetes, high blood pressure or high cholesterol. In a 68-week double-blind trial of nearly 2,000 obese adults without type 2 diabetes, half in the Semaglutide group lost at least 15% of their body weight, while almost a third lost 20% (those in the placebo growth lost less than 2.4%).

PEA Advanced + Collagen Complex II

PEA Advanced + Collagen Complex II contains a high-quality source of palmitoylethanolamide that aims to support joint inflammation and pain, along with many other benefits. It includes two clinically-studied ingredients that offer superior absorption and performance, Levagen+ and KollaGen II-xs.


Amlexanox has powerful anti-inflammatory properties that can help disrupt the strong cyclical link between chronic inflammation and weight gain. While researchers continue to study this link, clinical evidence shows that chronic inflammation and the body’s hormonal and metabolic response feed off each other in a vicious circle to produce increases in both inflammation and weight gains. Traditionally used to treat ulcers, Amlexanox can help break this cycle first by helping to reduce inflammation by inhibiting the body’s release of histamines and leukotrienes. But Amlexanox goes further by also regulating other enzymes in a manner that boosts glucose metabolism and improves overall energy. Additionally, researchers believe that the peptide can also turn off the expression of fat genes, which can further help patients lose weight. Overall, Amlexanox benefits identified in clinical trials include:
  • Reductions in body fat
  • Improved insulin resistance
  • Improved glucose control
  • Improvements in hemoglobin levels

Weight-loss doctors often combine Amlexanox with Tetradecylthioacetic Acid (TTA) to optimize potential weight-loss results.


Designed to support the body’s natural fat-burning abilities, Thermo-Suppress is a non-stimulant/caffeine-free supplement containing two clinically-studied proprietary ingredients with GRAS status paired with two widely-studied compounds that target several key areas of weight management.


A peptide with 29 amino acids, Sermorelin optimizes growth hormone levels in adults. It does this by acting as a growth hormone secretagogue – which means it promotes the body’s natural growth hormone production without many of the risks associated with taking growth hormone directly. By replacing natural occurring deficiencies, sermorelin improves hormonal balance, enhances energy, burns fat, increases lean muscle mass, improves sleep quality, enhances memory, and improves the sex drive. When combined with proper diet and exercise, the results can be dramatic within three months. Sermorelin’s ability to reduce daytime fatigue combined with its weight loss properties make it useful in treating patients with diabetes as well. Research also suggests that the peptide provides anti-aging benefits by enhancing the immune system and protecting natural DNA sequences.
Glycine is an amino acid and neurotransmitter that has been successfully used to treat prostate gland enlargement, insomnia, schizophrenia, and stroke. It is used in combination with Sermorelin to optimize growth hormone production. The two are taken together by subcutaneous injection five out of seven nights during a week, 90 minutes after the last caloric intake.

Dr. B uses Sermorelin injections in conjunction with Amlexanox for a highly effective Triple-Play Weight Loss Program. Call our office at 239-261-9990 to find out if this program can help you achieve your weight loss goals.



Found in every cell and tissue of the body, peptides play a critical role in a wide variety of essential bodily and health maintenance functions. Like proteins but with smaller amino acid chains, some peptides serve a building block role similar to that of proteins, while many others serve as cell messengers. Our bodies naturally produce thousands of different kinds of peptides, and our bodies absorb peptides that are naturally found in many foods.


As we age, our natural ability to produce and process peptides declines. Peptide therapy is designed to restore peptide levels in people who struggle to maintain the correct levels through foods and/or supplements. Developed on a patient-by-patient basis to address distinct peptide deficiencies, the therapy helps resolve specific health concerns by restoring appropriate peptide levels.


Peptides are administered topically, orally, or via injection, depending upon the peptide type and condition treated.


While researchers continue to unlock the secrets of peptides, they have discovered that some peptides play a crucial role in regulating metabolism, the body’s production of human growth hormone (HGH), and blood sugar levels. Boosting metabolism and HGH levels naturally encourages the body to burn more calories and fat reserves. Their influence on blood sugar levels helps slow digestion and decrease appetite. Additionally, some peptides have anti-inflammatory properties that, when engaged, allow the body to focus more energy on burning fat than on responding to the inflammation.


The therapeutic use of peptides continues to expand rapidly as researchers discover the unique properties and biological functions of new peptide types. Along with weight loss, benefits identified in peptides currently used for different therapies include:

  • Enhanced metabolism
  • Increased strength and muscle growth
  • Improved immune system response
  • Increased libido and sexual arousal
  • Enhanced concentration and memory retention
  • Decreased inflammation
  • Improved skin tone and elasticity
  • Decreased hair loss
  • Thicker hair and nails
  • Pain reduction
  • Improved sleep

Potential weight loss through peptide therapy with Dr. B will vary by patient as each presents a different profile concerning their starting weight, metabolism, eating and exercise habits, and approved peptide therapy. That said, in semaglutide clinical trials, many patients lost 10% of their body weight in about 20 weeks and another 5% to 10% after 68 weeks.


Researchers have identified several potential side effects, though these effects seem to be based more on a combination of factors relating to the patient’s health and amounts and administration method, rather than any specific peptide alone. Potential side effects include:

  • High blood pressure
  • Joint pain
  • Kidney pain
  • Fertility issues
  • Weight gain/weight loss
  • Skin discoloration
  • Nausea
  • Diarrhea
  • Fluid retention
  • Paresthesia (numbing, tingling, prickling, chilling, or burning sensation on the skin)
  • Xerostomia (dry mouth)

Peptide therapy should always be conducted under the supervision of a physician, and patients taking peptides should always notify their physician if they notice any significant changes to their health.

plans for medical weight loss medication and diet

If you are interested in medical weight loss in Naples, FL, or to see if weight loss medication is right for you, please call our office today at 239-261-9990 (ask for Camille at ext 102). 

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Fit2Me is a FREE Type 2 Diabetes Program that’s custom fit for you.

With activities and recipes chosen just for you, we provide you the tools to build meals and activity plans, including ways to trade off excess calories with additional activity. Fit2Me can also be used to choose fun activities that work with your schedule, keep track of doctor visits, and explore treatment information.

Fit2Me has 4 areas: My Food, My Activity, My Treatment Support, and My Plan Team.