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Hormone Replacement Therapy in Naples, FL

Balanced hormones, restored energy, and a plan built around your labs, not a one-size-fits-all script.

Hormone replacement therapy (HRT) restores the estrogen, progesterone, and testosterone your body makes less of with age, easing symptoms like fatigue, brain fog, low libido, hot flashes, and disrupted sleep. At Dr. B in Naples, FL, board-certified physician Dr. Diane Brzezinski and her provider team build personalized, lab-guided hormone therapy plans for both men and women across Southwest Florida.

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What Is Hormone Replacement Therapy?

Hormone replacement therapy is a physician-directed treatment that restores hormones, mainly estrogen, progesterone, and testosterone, that decline with age, menopause, or hormone imbalance. By returning these hormones to healthy levels, HRT can relieve symptoms and support energy, mood, sleep, bone strength, and sexual health.

HRT comes in several forms, including pills, patches, creams, injections, and long-acting pellets. The right form depends on your labs, your symptoms, and how you prefer to manage treatment. Not sure whether your symptoms are hormonal? Start with the common signs you may need hormone replacement therapy.

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Types of Hormone Therapy We Offer in Naples

Hormone therapy is not a single treatment. Dr. B’s team matches the method to your labs, symptoms, and lifestyle. Here is what that can look like:a

Hormone Therapy

Bioidentical Hormone Pellet Therapy:
Rice-sized pellets placed under the skin that release a steady dose of hormones for months.
See how pellet therapy works.

Hormone Therapy for Men (Low Testosterone):
Testosterone support for fatigue, low libido, and loss of strength tied to low T.
Explore male low testosterone treatment.

Hormone Therapy for Women (Menopause & Perimenopause):
Estrogen and progesterone support for hot flashes, night sweats, sleep, and mood.
Explore menopause symptom relief.

Peptide Therapy (complementary):
an adjacent option some patients add to support recovery, metabolism, and vitality.
Explore peptide therapy.

Pellets are one option, not the only one. Your consultation and bloodwork determine which approach fits you best.

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Bioidentical vs. Synthetic Hormones: What’s the Difference?

Bioidentical hormones are derived from plant sources and are molecularly identical to the hormones your body produces. Synthetic hormones are lab-made and structurally different. Both can be effective, and “bioidentical” does not automatically mean safer. What matters most is the right hormone, dose, and monitoring for you.

Bioidentical Hormones Synthetic Hormones
Source Plant-derived, identical to your own hormones Lab-made, structurally different
Common forms Pellets, creams, patches (compounded or FDA-approved) Oral tablets, some patches
Hormone levels Steady release, especially with pellets Can rise and fall like a “roller coaster”
Dr. B’s approach Personalized, lab-guided bioidentical plans Used when clinically appropriate for the patient

What Are Hormone Pellets?

Hormone pellets are one delivery method for HRT: bioidentical estrogen or testosterone compounded into pellets smaller than a grain of rice, placed in the fatty tissue just under the skin. They release hormones steadily for several months, most closely mimicking how healthy ovaries and testicles release hormones into the bloodstream.

Oral and transdermal forms can cause mood and energy to rise and fall like a roller coaster, because levels are hard to keep steady. Pellets deliver a consistent dose over time, so many patients avoid those swings. The implantation is a quick in-office procedure performed by your provider. Learn how hormone pellet therapy works.

Hormone Pellet Therapy

Who Is Hormone Therapy For?

Hormone therapy helps both men and women whose symptoms trace back to declining or imbalanced hormones. We confirm candidacy with bloodwork and a review of your health history.

Hormone Therapy for Women

For women in Naples, hormone therapy has helped with:

  • Menopausal and perimenopausal symptoms like hot flashes and night sweats
  • Maintenance of bone density
  • Restoration of sleep patterns
  • Improvement in sex drive, libido, and sexual performance
  • Relief of depression, anxiety, irritability, and mood swings

Research also points to potential benefits beyond symptom relief. One nine-year study found that women using testosterone pellet therapy had a lower incidence of invasive breast cancer than age-adjusted expected rates, and a large 2026 study associated hormone therapy use with a lower risk of dementia. These are associations reported in research, not guarantees, and they do not apply to everyone. Dr. B reviews your personal risk profile before recommending treatment.

Hormone Therapy for Men

In men, testosterone therapy can ease symptoms of low testosterone, including:

  • Fatigue and low energy
  • Lack of mental acuity or focus
  • Loss of libido
  • Erectile dysfunction

Testosterone therapy is prescribed to relieve the symptoms of low testosterone, and treatment includes ongoing monitoring, including prostate health, through periodic bloodwork. Learn more about male low testosterone treatment.

Meet the Providers Behind Your Hormone Care

Your hormone plan comes from a team, not a single doctor. Bloodwork guides every plan, and an experienced provider reviews it.
Dr. Diane Brzezinski

Dr. Diane Brzezinski, D.O., FACOI

board-certified internal medicine physician who has practiced in Naples for 25 years and is a multi-year Naples Daily News Reader’s Choice winner for Best Physician.

Read more

Dr. Michael Hellman, D.O.

physician on the Dr. B team providing hormone therapy for men and women.
Read more

Kelly Fennemore, MSN, ARNP

nurse practitioner who evaluates candidacy, administers therapy, and manages follow-up care.

Read more

What are Hormone Pellets?

  • Pellets contain a natural plant source of estrogen and testosterone. A compounding pharmacist, using strict federal guidelines, compounds the estrogen and testosterone utilized in the pellets.
  • These pellets, which are smaller than a grain of rice, are placed in the fatty tissue underneath the skin and most closely mimic the actions of healthy ovaries and testicles with regards to hormone release into the bloodstream. The hormone pellet implantation procedure is easily performed in the office by your hormone doctor or licensed nurse practitioner.

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Patient holding a relaxation mask before a hormone replacement procedure.

Breathe Easy with PRO-NOX™!

Ease anxiety and discomfort with PRO-NOX, a self-administered inhaled gas mixture of 50% oxygen and 50% soothing anesthetic. It relieves pain and anxiety through the anesthetic’s numbing action, while the oxygen lets you breathe naturally.

Learn more about PRO-NOX

What our patients have to say about Hormone Pellet Therapy…*

Connie M.

I was always tired, never slept, achy, couldn’t remember anything and absolutely no libido. Then Dr. B checked my hormone levels, which were very low and talked to me about Bio-identical hormone pellets. I went to one of her seminars and it seemed like everyone there had the same symptoms that I was having and how great they worked for them. I went on March 7th to Dr. B and I got my first pellets, and the very same night I slept all night at least 8 hours and woke up in amazement. Every night since I am sleeping like a baby, so of course I have much more energy and feel so much better. Besides all that, my “brain fog” that was getting increasing worse since menopause, lifted. Even my husband noticed that I wasn’t struggling to remember the right word or losing my keys. And killing him in trivia again. And don’t even get me started about my libido, huge difference. All in all, I am extremely happy with the difference in my life since the hormone pellets, I feel like myself again. Would highly recommend these to anyone suffering from the side effects of menopause and aging. †
Hormone Therapy Naples FL Patient

N, 58 years old

I have never been on any kind of hormone replacement therapy, and Dr. B suggested I might get benefits out of the Hormone Pellet Therapy. I thought I would give it a try, and I can’t believe the change it’s made in my life!!! I have so much energy, sleep like a baby, wake up refreshed, and my libido has gone from nothing, to amazing. My husband asks me “where is my wife, and what have you done with her??” Needless to say, we are both very happy with this change.†
Hormone Therapy Naples FL Patient

*Results tend to vary among patients

Hormone Replacement Therapy Serving Naples and Southwest Florida

Dr. B provides hormone replacement therapy at the practice’s Naples office, welcoming men and women from across Southwest Florida who want discreet, physician-led hormone care.

Patients travel to Dr. B from across Southwest Florida, including:

  • Naples and North Naples
  • Bonita Springs and Estero
  • Marco Island
  • Fort Myers and the surrounding area

The office is located at 1250 Pine Ridge Rd Ste 101A, Naples, FL 34108. If you are searching for hormone replacement therapy near you in the Naples or Fort Myers area, Dr. B’s team is ready to help. Call (239) 261-9990.

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Naples, FL

Watch Dr. B’s Bioidentical Hormone Therapy Webinar

Dr. Brzezinski shares a recent presentation on the health effects of bioidentical hormone therapy in men and women, including her own journey and the top myths about hormones and HRT.

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Frequently Asked Questions About Hormone Replacement Therapy in Naples

What is hormone replacement therapy?

Hormone replacement therapy restores hormones, mainly estrogen, progesterone, and testosterone, that decline with age, menopause, or imbalance. By returning them to healthy levels, HRT can relieve symptoms like fatigue, hot flashes, low libido, and brain fog, and support sleep, mood, and bone strength.

What are the signs I need hormone replacement therapy?

Common signs include persistent fatigue, hot flashes, night sweats, disrupted sleep, brain fog, low libido, mood changes, and unexplained weight changes. Only bloodwork can confirm whether your symptoms are hormonal. See the full list of signs you may need HRT.

Is hormone replacement therapy safe?

For many healthy adults, HRT is a well-studied option when prescribed and monitored appropriately. Safety depends on your age, health history, timing, and the type of hormones used. In late 2025, the FDA moved to remove outdated boxed warnings from estrogen menopause therapy. Read is HRT safe for women.

Does hormone replacement therapy cause cancer?

It depends on the hormones and the person. Estrogen taken alone can raise the risk of endometrial cancer in women who still have a uterus, which is why progesterone is added. Research on breast cancer risk is mixed, and some studies of testosterone pellet therapy have reported lower breast cancer incidence. Dr. B reviews your personal risk before recommending treatment.

How much does hormone replacement therapy cost in Naples?

Cost varies by the type of therapy, your dosing, and how often pellets or refills are needed, so pricing is confirmed at your consultation. New patients can mention the current coupon for 25% off a first hormone therapy treatment.

Is HRT covered by insurance?

Coverage varies by plan and by the specific therapy. Some lab work and FDA-approved hormone medications may be covered, while compounded and pellet options are often out of pocket. The team can help you understand your options at your visit.

How long does hormone therapy take to work?

Many patients notice improvements in energy, sleep, and mood within the first few weeks, with fuller benefits building over one to three months as levels stabilize. Your provider tracks progress with follow-up bloodwork and adjusts your plan as needed.

How long do hormone pellets last?

Hormone pellets typically last three to six months before they need to be replaced, depending on the individual and the dose. Dr. B will plan a schedule that fits your body and lifestyle.

Who is a good candidate for hormone therapy?

Adults with symptoms of low or imbalanced hormones confirmed by bloodwork are often good candidates. People with a history of certain cancers, blood clots, or liver disease may not be, which is why every plan starts with an evaluation of your health history.

Ready to Feel Like Yourself Again in Naples?

Balanced hormones can mean better energy, sharper focus, deeper sleep, and a stronger libido. Start with a consultation and bloodwork, and let Dr. B’s team build a plan around your results.

Book an Appointment

Prefer to call? Reach the office at (239) 261-9990.